Prolent^TM

Balance between inhibitory and excitatory neurotransmitter activity is vital to health and well-being. Inhibitory neurotransmitters such as serotonin, GABA and glycine balance excitatory signals in the nervous system. That is why supporting inhibitory neurotransmitters often results in balanced calming and relaxing effect.  

Prolent includes ingredients that support the optimal action of inhibitory neurotransmitters.* 5-HTP and vitamin B6 support serotonin synthesis.* Theanine, as Suntheanine®, supports both the release of GABA and its function.*¹ The combination of these ingredients along with glycine allows Prolent™ to offer comprehensive support for balanced inhibitory neurotransmission.*

The NeuroSupport Blend™ (NSB) is designed to enhance absorption to support the impact of ingredients.* 

Prolent helps promote balance with catecholamine activity and could be considered with other support.* It may be combined with Lentra™, SomniTR™, or Tranquilent™ for added inhibitory support.*

L-theanine as Suntheanine® (standardized to >99%): L-Theanine intake is shown to restore balanced relaxation by balancing multiple internal mechanisms, leading to increased healthy GABA activity and decreased norepinephrine activity.*^1,2

5-HTP: A naturally occurring amino acid and metabolite of L– tryptophan. 5-HTP is the direct precursor in the biosynthesis of serotonin.* Use of 5-HTP avoids the rate-limiting conversion of tryptophan to 5-HTP. 

Glycine: Functions as an inhibitory neurotransmitter, primarily in the brainstem and spinal cord.*³

Vitamin B6 (as pyridoxal-5’-phosphate): Active form of B6. Cofactor in conversion of 5-HTP to serotonin.* 

NeuroSupport Blend™ (NSB): Proprietary mixture composed of Bioperine® and plant-based enzymes designed to maximize nutrient absorption.* 

Serving Size: 1 Capsule
Servings Per Container: 60 Capsules

Prolent™ Formula  295mg  
Vitamin B6 (as pyridoxal-5-phosphate)
Glycine
L-theanine (as Suntheanine®)
5-hydroxytryptophan (Griffonia simplicifolia) (seed)

NSB™ Proprietary Blend  102.5mg
BioPerine® (Black Pepper Extract) (standardized to 95% piperine)(Piper nigrum) (fruit)
Protease
Amylase
Lipase

NSB™ is a trademark of Sanesco International Inc.

BioPerine® is a registered trademark and a product of Sabinsa Corp.

Suntheanine® brand L-Theanine is a registered trademark of Taiyo International, Inc.Suntheanine® is Generally Recognized as Safe (GRAS) & is Non-GMO Project Verified. 

GABA, serotonin and glycine activity work together to balance: 

• Optimal sleep^4,13
  
• Balanced calm and relaxation^4,14
  
• Healthy mood⁴
• Regulating excitability⁴
• Maintaining mental and emotional health (including healthy mood and anxiousness)⁵
• Optimal learning⁵
• Balanced stress response⁶
• Appetite and balanced cravings⁷
• Occasional aches and discomfort
• Healthy libido⁹
• GI motility¹⁰
• Thermoregulation balance¹¹
• Menstrual health¹² 

1. Nathan PJ, et al. 2006. J Herb Pharmacother. 6:21–30.
2. Kimura and Morata. Chem Parhm Bull (Tokyo). 1986. Jul; 34 (7) 3053.7.
3. Bannai M, et al. Psychiatry and Clinical Neurosciences. 2011 Mar;65(2), 142-149.
4. Ngo D and Vo TS. Molecules. 2019;24(15):2678. 
5. Longone P, et al. Frontiers in endocrinology. (2011):2.  
6. Moller SE. (1992). Serotonin, carbohydrates, and atypical depression. Pharmacol Toxicol. 71 Suppl 1:61-71. Slide 19,20
   
7. Wurtman J and Wurtman R. Curr Obes. Rep. 2018 Mar;7(1):1-5.
8. Ho KY, et al. Br J Anaesth. 2010 Setp;105(3):371-6.
9. Hull EM, et al. Physiology and Behavior. 2004 Nov;83(2):291-307.
10. Crowell MD. Br J Pharmacol. 2004 Apr;141(8):1285-93.
11. Rybaczy LA, et al. BMC Women’s Health. 2005. 
12. Yonkers KA, et al. ancet. 2008 Apr 5;371(9619):1200-1210.
13. Bravo R, et. al. Age (Dordr). 2013 Aug;35(4):1277-86.
14. Tauscher J, et al. The Amer J of Psychiatry. 2001 Aug 1;158(8):1326-1328.